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Effect of ionization of drug on drug solubilization in SMEDDS prepared using Capmul MCM and caprylic acid

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Graphical Abstract Upon dispersion of drug-loaded SMEDDS in aqueous media at various pHs, four drug-related species – Du, Di, Du-SMEDDS and Di-SMEDDS – contribute to total drug solubilization in the… Click to show full abstract

Graphical Abstract Upon dispersion of drug-loaded SMEDDS in aqueous media at various pHs, four drug-related species – Du, Di, Du-SMEDDS and Di-SMEDDS – contribute to total drug solubilization in the formed microemulsions. Distinct solubilization behavior was observed for neutral, weak acidic and weak basic drugs due to various extent of drug ionization.Unlabelled image

Keywords: effect ionization; drug; solubilization; ionization drug; drug solubilization; drug drug

Journal Title: Asian Journal of Pharmaceutical Sciences
Year Published: 2017

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