Graphical Abstract Upon dispersion of drug-loaded SMEDDS in aqueous media at various pHs, four drug-related species – Du, Di, Du-SMEDDS and Di-SMEDDS – contribute to total drug solubilization in the… Click to show full abstract
Graphical Abstract Upon dispersion of drug-loaded SMEDDS in aqueous media at various pHs, four drug-related species – Du, Di, Du-SMEDDS and Di-SMEDDS – contribute to total drug solubilization in the formed microemulsions. Distinct solubilization behavior was observed for neutral, weak acidic and weak basic drugs due to various extent of drug ionization.Unlabelled image
               
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