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STUDY'S GOAL As there are no guidelines. This short report shows our experience in management of sub-acute limb ischemia with polyarteritisnodosa. INTRODUCTION Acute limb ischemia is rarely seen in periarteritisnodosa. CASE REPORT Here, we present a case with peripheral vascular disease of both lower limbs leading to foot claudication and then a subacute limb ischemia with large necrotic plaques on the lower limb. Angioscan showed occlusion of both superficial femoral arteries. Angiographic imaging showed abnormalities in medium-sized arteries. Pathological study of biopsy from the artery, vein, nerve and skin of the amputated leg confirm the diagnosis of periarteritisnodosa. She benefited from femoral popliteal bypass in both legs, anticoagulant drug and steroids. The non-amelioration of the left leg led to his amputation. The right leg was healed.