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The search identified 282 abstracts, of which 4 double-blind randomized controlled trials (345 patients, 171 placebo and 174 probiotic) met the inclusion criteria. All studies used the same probiotic, manufactured… Click to show full abstract
The search identified 282 abstracts, of which 4 double-blind randomized controlled trials (345 patients, 171 placebo and 174 probiotic) met the inclusion criteria. All studies used the same probiotic, manufactured by the same company and given at the same dose, and the same placebo. All trials included breastfed infants with colic, whereas only one trial included formula-fed infants with colic. The probiotic group was approximately twice as likely as the placebo group to experience treatment success at 7, 14, and 21 days (adjusted incidence ratios were 2.08 [95% CI 1.26 to 3.42], 1.98 [95%CI 1.46 to 2.70], and 1.71 [95% CI 1.35 to 2.15], respectively) (Table). In subgroup analysis, the duration of crying or fussing was decreased in the breastfed infants at all time points but not in the
Journal Title: Annals of Emergency Medicine
Year Published: 2019
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