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HighlightsODE‐Bn‐PMEG abolishes human papillomavirus productive infection in 3D cultures of primary human keratinocytes (PHKs).Incorporation of activated ODE‐Bn‐PMEG into replicating DNA causes DNA breaks and abolishes viral activities.ODE‐Bn‐PMEG induces apoptosis selectively… Click to show full abstract
HighlightsODE‐Bn‐PMEG abolishes human papillomavirus productive infection in 3D cultures of primary human keratinocytes (PHKs).Incorporation of activated ODE‐Bn‐PMEG into replicating DNA causes DNA breaks and abolishes viral activities.ODE‐Bn‐PMEG induces apoptosis selectively in HPV‐infected, differentiated keratinocytes while sparing uninfected tissues.Cidofovir, which is used to treat human cytomegalovirus retinitis, neither induces apoptosis nor abolishes HPV activity.With its efficacy, selectivity and mechanism of action, ODE‐Bn‐PMEG strongly merits further development and clinical trials.
Journal Title: Antiviral Research
Year Published: 2018
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