LAUSR

&NA; The real‐world effectiveness and safety of all‐oral direct‐acting antivirals (DAAs) for chronic hepatitis C (HCV) infection and chronic kidney disease (CKD) have not been fully elucidated. This study assesses elbasvir (EBR) plus grazoprevir (GZR) for patients with HCV genotype 1 infection in the clinical setting, focusing on CKD stage 3‐5D. This multicenter, real‐world cohort study consisted of 282 Japanese patients who were treated with EBR (50 mg) plus GZR (100 mg) for a fixed 12‐week duration. We evaluated the sustained viral response rate 12 weeks after the end of treatment (SVR12), longitudinal liver and renal parameters, and adverse effects according to the cirrhosis and CKD status. Of those enrolled, 89 (31.6%) were CKD stage 3–5 and 21 (7.4%) were CKD stage 5D (hemodialysis‐dependent). The overall and CKD stage 3‐5D SVR12 rates in the per protocol populations were 98.6% (272/276) and 98.1% (101/103). High SVR12 rates were observed in almost all groups, except for prior all‐oral DAA failure with NS5A resistance‐associated substitutions. There was no significant change during treatment or follow‐up period in estimated glomerular filtration rate, irrespective of CKD status. In contrast, the serum complement level (C3 and C4) increased, with significance for C3. Serious adverse effects were very rare, both in the groups with normal eGFR and CKD, and discontinuation was required for only six (2.1%) patients. EBR plus GZR for HCV genotype 1 was highly effective with a low rate of adverse effects, regardless of CKD status. In addition, liver parameters and complement levels improved longitudinally. HighlightsThe SVR12 rates for HCV genotype 1 patients with CKD 3–5 and 5D (dialysis) in EBR/GZR were 98.8% and 95.0%, respectively.Neither of the patients who had experienced all‐oral DAA treatment with asunaprevir plus daclatasvir achieved SVR12.The longitudinal eGFR level of patients with CKD stage 3–4 did not improve during treatment or the follow‐up period.Patients with CKD stage 3–4 had improved C3 and C4 complement levels, with significance for C3.Severe ALT elevation occurred rarely and that it was reversible, with no evidence of hepatic decompensation.