LAUSR

Introduction Tacrolimus is the basis of immunosuppressive treatment in liver transplantation, with dosages of blood levels to ensure adequate graft function. In Peru, since 2005 generic tacrolimus has been used exclusively in all transplant centers due to lower costs. There are no presentations (0.5 mg), necessary for its use in a group of transplanted patients who require low doses of the drug. Objectives To show the results of the use of low doses ( Methods Observational, descriptive, cross-sectional, and retrospective study. Demographic data, transplant time, dose and blood levels of tacrolimus, rejection, and adverse effects were obtained from electronic medical records from October to December 2020. Inclusion criteria: adults, doses: 3 months use of generic tacrolimus (NORGRAF: The Madras Pharmaceuticals, India) using 0.5 mg capsules, prepared by the Pharmacy Service at the Guillermo Almenara Hospital. Exclusion criteria: Pediatrics, retransplant, combined transplant. Statistical analysis and processing was using SPSS 23. Results Eleven of 246 patients (4.52%) were identified. All patients had blood levels within the therapeutic range in relation to transplantation time and graft function. Average daily dose: 1.3 mg (0.5-1.5 mg /d). Average blood levels: 5.82 ng/L (3.57-10.3 ng / ml). Average transplant time: 73 months (3-120 months). There were no rejection episodes or adverse effects of nephrotoxicity, neurotoxicity, or infections. Conclusion The use of low doses of generic tacrolimus (