LAUSR

Abstract With increasing competition in the pharmaceutical industry, pharmaceutical companies pay more attention to improving the efficiency of clinical trial supply chains to reduce the drug supplying cost, which takes up a considerable part of the total research and development expense. To improve the efficiency of clinical trial supply chains, this study investigates the inventory levels of clinical drugs in each period at a distribution center and clinics considering the reverse replenishment, transshipment, and generalized stockout cost. The inventory allocation problem in clinical trial supply chains is formulated as a rolling horizon-based two-stage stochastic mixed-integer model where the minimal operational cost constitutes the underage cost at the production planning level of clinical trial supply chains. An algorithm extending Benders decomposition is proposed as the solution approach. We also derive several structural results and develop the reformulation method and row generation strategy to improve the efficiency of the optimization process. The effectiveness of our approach is demonstrated in the numerical experiment.