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OBJECTIVE To examine the association between the number of physical and occupational therapist visits received in the acute care hospital and the risk of hospital readmission or death. DESIGN Retrospective cohort study of electronic health records and administrative claims data collected for 2.25 years (January 1, 2016 - March 30, 2018). SETTING 12 acute care hospitals in a large healthcare system in Western Pennsylvania. PARTICIPANTS 8,279 adults discharged with a primary stroke diagnosis. INTERVENTIONS The exposure was number of physical and occupational therapist visits during the acute care stay. MAIN OUTCOME MEASURE(S) Generalized linear mixed models were estimated to examine the relationship between therapy use and 30-day and 7-day hospital readmission or death (outcome), controlling for patient demographic and clinical characteristics. RESULTS The 30-day and 7-day readmission or death rate was 16.0% and 5.7% respectively. The number of therapist visits was inversely related to the risk of 30-day readmission or death. Relative to no therapist visits, the odds of readmission or death was, 0.70 [95% CI, 0.54-0.90] for individuals who received 1-2 visits; 0.59 [95% CI, 0.43-0.81] for 3-5 visits; and 0.57 [95% CI, 0.39-0.81] for >5 visits. A similar pattern was seen for the 7-day outcome with slightly larger effect sizes. Effects were also greater in individuals with more mobility limitations on admission and for those discharged to a post-acute care facility versus home. CONCLUSIONS There was an inverse relationship between the number of therapist visits and risk for readmission or death for patients with stroke discharged from an acute care hospital. Effects differed by time to the event (30 vs. 7 days) discharge location and mobility limitations on admission.