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Abstract In view of the problem that medical materials are prone to contamination by bacteria that causing health threats, an antibacterial surface was designed by combining mussel-inspired chimeric protein with… Click to show full abstract
Abstract In view of the problem that medical materials are prone to contamination by bacteria that causing health threats, an antibacterial surface was designed by combining mussel-inspired chimeric protein with silver nanoparticles (AgNPs). The mussel-inspired chimeric proteins have ability to adhere to various substrates through a convenient “one-step” method on account of 3,4-dihydroxyphenyl-alanine (DOPA), and serve as fixed templates to generate AgNPs. The prepared AgNPs protein coatings (Ag-MAP-KE) maintained prominent antifouling property with 97.9% E. coli shielding. In addition, the Ag-MAP-KE also exhibited excellent inhibitory performance against gram-negative bacteria E.coli and gram-positive bacteria S.aureus with 19.97 mm and 17.60 mm inhibition zone, and can be stimulated with water to release 99% covered bacteria. Furthermore, the designed funtionals coatings displayed excellent blood and cell compatibility. The cooperation of protein and AgNPs presents a noval“kill-release” strategy for developing antibacterial surfaces.
Journal Title: Applied Surface Science
Year Published: 2021
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