LAUSR

Abstract The present study was designed to evaluate the effects of dietary cytidine monophosphate on growth, blood characteristics, innate and adaptive immune functions and stress resistance of juvenile red sea bream, Pagrus major . A semi-purified basal diet supplemented with 0% (Control), 0.1% (CMP-0.1), 0.2% (CMP-0.2), 0.4% (CMP-0.4) and 0.8% (CMP-0.8) purified CMP to formulate five experimental diets. Each diet was randomly allocated to triplicate groups of fish (mean initial weight 2.9 g) for 56 days. In general dietary CMP supplementations tended to improve growth performances (final body weight, % weight gain and specific growth rate), in which significantly highest performances were found in diet group CMP-0.4 followed by diet groups CMP-0.8 and CMP-0.2. CMP supplementation resulting in increased feed conversion efficiency and protein efficiency ratio and highest value (P   0.05) with dietary CMP supplementations. Dietary supplementation of CMP had an increase (P > 0.05) adaptive humoral immune responses (antibody titer) after 21 days of vaccination of formalin killed Vibrio anguillarum . In terms of oxidative stress diet groups CMP-0.2 and CMP-0.4 showed best condition with low oxidative stress and high antioxidant levels. Moreover, the fish fed CMP supplemented diets had better improvement (P