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Abstract Copper (Cu) is a common contaminant in water and can potentially cause hepatic tissue damage and toxicity in aquatic organisms. Herein we performed transcriptome analysis to investigate the effects… Click to show full abstract
Abstract Copper (Cu) is a common contaminant in water and can potentially cause hepatic tissue damage and toxicity in aquatic organisms. Herein we performed transcriptome analysis to investigate the effects of 100 μg/L and 400 μg/L Cu2+ (96-h exposure) on hepatic lipid metabolism in swamp eel (Monopterus albus). We identified 1004 and 2766 differentially expressed genes (DEGs) in the 100 and 400 μg/L Cu2+ groups, respectively. 4 up-regulated DEGs (e.g. DGAT2 and SRD5A1) and 25 down-regulated DEGs related with lipid metabolism (e.g. FABP7A, CYP51, FADS2 and ACAA2) were found in 100 μg/L Cu2+ group. In 400 μg/L Cu2+ group, 52 up-regulated lipid metabolism genes (e.g. PPARα, RXRα, ACSL4A, CPT-1, CPT-2, ACOX3, HADHA and ACADL) were identified, and 22 genes related with lipd metabolism including FABP7A, CYP51, CYP27B1, etc. were significantly down-regulated (p
Journal Title: Aquaculture
Year Published: 2022
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