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One-pot sequential synthesis of O-(halo-substituted benzyl) hydroxylammonium salts

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Abstract In this study, we described a simple one-pot preparation of O -(halo-substituted benzyl) hydroxylamine derivatives by O -benzylation of N -hydroxyurethane, followed by basic N -deprotection. The advantages of… Click to show full abstract

Abstract In this study, we described a simple one-pot preparation of O -(halo-substituted benzyl) hydroxylamine derivatives by O -benzylation of N -hydroxyurethane, followed by basic N -deprotection. The advantages of the method were the chemo- and regio-selectivity in obtaining the desired O -benzyl hydroxylammonium salts in a high yield as well as the simplicity of the purification process.

Keywords: halo substituted; benzyl hydroxylammonium; one pot; hydroxylammonium salts; substituted benzyl

Journal Title: Arabian Journal of Chemistry
Year Published: 2017

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