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Abstract A series of novel N -acylsulfonamide derivatives were synthesized and characterized by 1 H NMR, 13 C NMR and HRMS. The N -acylsulfonamides were prepared in four steps (carbamoylation,… Click to show full abstract
Abstract A series of novel N -acylsulfonamide derivatives were synthesized and characterized by 1 H NMR, 13 C NMR and HRMS. The N -acylsulfonamides were prepared in four steps (carbamoylation, sulfamoylation, deprotection and acylation) starting from chlorosulfonyl isocyanate. These compounds were evaluated in vitro as antimicrobial agents against representative strains of Gram-positive ( Staphylococcus aureus ) and Gram-negative ( Escherichia coli , Acinetobacter , Klebsiella pneumonia and Pseudomonas aeruginosa ).
Keywords:
novel;
synthesis antibacterial;
novel acylsulfonamides;
activity novel;
chemistry;
antibacterial activity
Journal Title: Arabian Journal of Chemistry
Year Published: 2017
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Journal Title: Arabian Journal of Chemistry
Year Published: 2017
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!