LAUSR

Abstract The evaluation of the antioxidant, antibacterial and enzyme inhibition effects of N 2 O 2 Schiff base Zn complex was investigated. The percentage scavenging activity of hydroxyl radical (IC 50 -0.21 μg), ABTS (IC 50 -0.19 μg) and DPPH (IC 50 -0.25 μg) shows that ZnL complex had a potential antioxidant activity. The antibacterial activity of ZnL complex was evaluated. Results showed that MIC value against Staphylococcus aureus and Salmonella typhi was 100 and 200 μg/ml, respectively. ZnL complex showed strong inhibition toward α-amylase and α-glucosidase with an IC 50 value of 0.18 and 0.23 μg, respectively. The inhibition mechanism was analyzed with LB and Dixon plots. The ZnL complex could be a mixed noncompetitive and noncompetitive inhibitor with K i values of 77.8 and 31.6 μg for α-amylase and α-glucosidase, respectively. The preliminary assessment of ZnL complex showed that they can be used as an antioxidant, antibacterial and antidiabetic agents.