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A novel and convenient oxidation-controlled procedure for the synthesis of oxazolines from TosMIC and aldehydes in water – Anti biofilm activity

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Abstract A new convenient procedure for the synthesis of oxazolines from tosylmethyl isocyanide (TosMIC) and aldehydes using imidazole as an efficient catalyst has been reported. The synthesized oxazolines were able… Click to show full abstract

Abstract A new convenient procedure for the synthesis of oxazolines from tosylmethyl isocyanide (TosMIC) and aldehydes using imidazole as an efficient catalyst has been reported. The synthesized oxazolines were able to be protected from the oxidation by using just water both as a good solvent and anti oxidant. All the synthesized compounds show good anti biofilm activity against Staphylococcus epidermidis.

Keywords: tosmic aldehydes; anti biofilm; biofilm activity; synthesis oxazolines; procedure synthesis

Journal Title: Arabian Journal of Chemistry
Year Published: 2020

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