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Abstract In the current research, two porous Co(II)-containing metal-organic frameworks (MOFs) whose chemical formulae can be teamed as [Co2(bptc)(H2O)2]·5DMA (1, H4bptc = biphenyl-3,3′,5,5′-tetracarboxylic acid) and [Co2(Hatta)2·(H2O)3]·3DMA (2, H4atta = 2′-amino-[1,1′:4′,1″-terphenyl]-3,3″,5,5″-… Click to show full abstract
Abstract In the current research, two porous Co(II)-containing metal-organic frameworks (MOFs) whose chemical formulae can be teamed as [Co2(bptc)(H2O)2]·5DMA (1, H4bptc = biphenyl-3,3′,5,5′-tetracarboxylic acid) and [Co2(Hatta)2·(H2O)3]·3DMA (2, H4atta = 2′-amino-[1,1′:4′,1″-terphenyl]-3,3″,5,5″- tetracarboxylic acid) have been solvothermally synthesized by using two similar tetracarboxylic ligands and structurally characterized. The complex 2 with amino-functionalized pores could be used as recoverable heterogeneous catalytic agent for Knoevenagel condensation without solvents. The inhibitory activity of compounds on the scar tissue hyperplasia was evaluated and the related mechanism was discussed as well. First of all, the proliferation of the human hypertrophic scar fibroblasts was measured after indicated treatment was measured by CCK-8 assay. Next, the real time RT-PCR was applied to determine the activation power of the VEGF signaling pathway after using compounds.
Journal Title: Arabian Journal of Chemistry
Year Published: 2020
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