LAUSR

This study longitudinally investigates the effect of depressive disorder on psychiatric disorder in middle aged and aged population from the Korean Longitudinal Study of Aging. Data from the Korean Longitudinal Study of Aging (KLoSA) from 2006 to 2016 was assessed using longitudinal data analysis and 7515 research samples were included after excluding those with cognitive decline and missing information at baseline (2006). To analyze the association between depressive disorder on cognitive decline in middle aged and aged population, generalized estimating equation (GEE) model and chi-square test were used. The association between depressive symptom during a week and center for epidemiological studies depression (CESD) on cognitive decline was statistically significant, respectively with the following Odds ratio (OR) predicting decreased MMSE score: OR = 0.89 (p < .0001) for 5-7 days vs. less than a day and B = 0.91 (p < .0001) for depression (8-10) vs. healthy (zero). In terms of cognitive decline, depressive symptom was higher for 5-7 days (OR = 3.79, p < .0001) compared to less than a day. This study shows a statistically significant association between depressive disorder and cognitive decline in a Korean middle aged and aged population. These findings suggest the importance of managing depressive disorder for incident cognitive decline.