LAUSR

s 89 young. In the older adults, neither FMD (SALS: 3.5 1.4 to 4.6 1.2%; PLAC: 3.4 1.2 to 2.5 1.3%, ANOVA PZ 0.98) nor CFPWV (SALS: 8.1 0.5 to 8.4 0.6 m/sec; PLAC: 7.6 0.5 to 7.6 0.4 m/sec, ANOVA PZ 0.41) was altered after 4 weeks of salsalate vs. placebo. These data fail to demonstrate that chronic salsalate timproves ageassociated aortic stiffness or endothelial dysfunction in older adults. Future studies should test longer duration therapy or more selective inflammatory inhibitors on vascular aging in humans. P96 ACUTE EFFECT OF ELECTRONIC CIGARETTE SMOKING ON PULSE PRESSURE AMPLIFICATION IN YOUNG SMOKERS Nikolaos Ioakeimidis, Dimitris Terentes-Printzios, Christos Georgakopoulos, Charalambos Vlachopoulos, Mohammed Abdelrassoul, Ioanna Gourgouli, Nikolaos Magkas, Dimitrios Tousoulis 1st Department of Cardiology, Hippokration Hospital, Athens Medical School, Greece Purpose/Background/Objectives: We investigated the acute effect of electronic cigarette (EC) smoking on the aortic pressure waveform amplification. We also sought to compare the effect of EC and combustible cigarette (TC) smoking on central haemodynamics. Methods: We studied 24 smokers (age: 30 8 years) on 3 separate occasions: a) tobacco cigarette (nicotine content, 1.2 mg) over 5 minutes, b) EC (18mg E-liquid) for a period of 30 minutes, and c) nothing (sham procedure) for 60 minutes. Smoking EC for 30 min (15 puffs) was chosen to mimic the common pattern of EC smoking. Results: Both TC and EC smoking caused a significant increase in brachial pressures and heart rate (HR), and the differences in blood pressure (BP) and HR responses between the two smoking forms were not significant. The aortic pressures also increased significantly after smoking both TC and EC, with the greatest changes seen in the first 5 minutes after TC smoking and 15 minutes EC smoking (figures 1AC, all P< 0.05). Although AIx, decreased in both two smoking forms, by applying a correction factor for changes in HR, the AIx increased significantly after TC (by 3.0% at 5 minutes, P< 0.05) and EC (by 2.9% at 15 minutes, P< 0.05) (figure 1D). Conclusions: Electronic cigarette smoking exerts an unfavourable and comparable to that of TC smoking acute effect on aortic pressure waveform amplification. Given the prognostic role of central haemodynamics on cardiovascular disease risk, EC may still be considered a hazardous smoking method. P98 EFFECT OF LONG-TERM ANDROGENIC TREATMENT ON THE STRUCTURAL AND FUNCTIONAL PROPERTIES OF THE GREAT ARTERIES OF FEMALE