LAUSR

s 85 References 1. van den Hoogen F, Khanna D, Fransen J, Johnson SR, Baron M, Tyndall A, et al. 2013 classification criteria for systemic sclerosis: an American College of Rheumatology/European League against Rheumatism collaborative initiative. Arthritis Rheum 2013 Nov;65(11):2737e2747. P18 AORTIC STIFFNESS IN AORTIC STENOSIS: SHORT TERM HEMODYNAMIC CHANGES AFTER TRANSCATHETER AORTIC VALVE IMPLANTATION Jeannette Goudzwaard, Nahid El Faquir, Nicolas van Mieghem, Marjo de Ronde-Tillmans, Mattie Lenzen, Peter de Jaegere, Francesco Mattace-Raso Erasmus University Medical Center, Rotterdam, the Netherlands Background: Both aortic valve stenosis as aortic stiffness are moderators of arterio-ventricular coupling and independent predictors of cardiovascular morbidity and mortality. Studies on the effect of Transcatheter Aortic Valve Implantation (TAVI) on hemodynamic parameters are limited. We performed a pilot study to investigate possible short-term hemodynamic changes after TAVI in older patients. Methods: TAVI Care & Cure is an observational ongoing study including consecutive patients undergoing TAVI procedure. Central and peripheral hemodynamic measurements were measured non-invasively 1 day before (T0) and 1 day after (T1) TAVI using a validated oscillometric method using a brachial cuff (Mobil-O-Graph). Results: 40 patients were included. Mean aortic valve area at baseline was 0.73 0.18 cm. As expected indices of severity of the aortic valve stenosis improved. Systolic blood pressure (SBP) dropped by 8.5%, from 130.3 22.9mmHg to 119.5 15.8mmHg (pZ 0.005). Diastolic blood pressure (DBP) dropped by 13.1 % from 74.8 14.5 mmHg to 65.0 11.3 mmHg (p < 0.001). The aPulse Wave Velocity (aPWV) decreased from 12.05 1.99 m/s to 11.6 1.56 m/s (p Z 0.006)(Fig. 1). Patients with high aPWV at baseline showed a significantly larger reduction in SBP in comparison to patients with low aPWV: 20.3 mmHg (-14,1%) vs e 3,1 mmHg (-2.6%), respectively (p Z 0.033). The same trend was found for the DBP: -16.2 (-20.4%) v.s. -4.5 mmHg (-6.3%) for high vs. low aPWV at baseline (pZ0.037). Conclusion: We found short term changes of blood pressure and aortic stiffness after TAVI. The amplitude of the changes was the largest in patients with elevated aortic stiffness at baseline. P19 EFFECT OF GROWTH HORMONE REPLACEMENT IN THE VASCULAR SYSTEM OF ADULT PATIENTS WITH CHILDHOOD ONSET