LAUSR

s / Atherosclerosis 263 (2017) e111ee282 e146 (79.82±15.25% vs. 74.51±5.87%;p1⁄40.274 for fibrotic and 2.83±2.60% vs. 2.40±1.58%;p1⁄40.617 for calcific tissue). Both patient groups had similar plaque necrolipidic tissue content (17.8±13.49% vs. 23.10±5.35%;p1⁄40.219 in prediabetic vs. diabetic patients). Fasting glucose, HbA1c and lipid parameters did not show correlation with plaque tissue characteristics in prediabetic patients. C peptide had negative correlation with fibrotic (r1⁄40.65;p1⁄40.009) and positive correlation with necrotic (r1⁄40.70;p1⁄40.004) and calcific tissue content(r1⁄40.52;p1⁄40.046). Conclusions: Prediabetic patients had similar plaque vulnerability with lower lipidic tissue content as patients with diabetes. C peptide was an independent predictor of lower fibrotic and higher necrotic and calcific tissue content suggesting its relation with plaque vulnerability. PO110. NILE RED QUANTIFIER: A NOVEL AND QUANTITATIVE TOOL TO STUDY LIPID ACCUMULATION IN PATIENT-DERIVED CIRCULATING MONOCYTES USING CONFOCAL MICROSCOPY Jan Schnitzler, Feiko Tiessens, Sophie Bernelot Moens, Geesje Dallinga-Thie, Albert Groen, Erik Stroes, Jeffrey Kroon. Department of Vascular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands; Department of Experimental Vascular Medicine, Academic Medical Center, University of Amsterdam, Amsterdam, The Netherlands; Department of Pediatrics, Laboratory of Metabolic Diseases, University of Groningen, UMCG, Groningen, The