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Reparative effects of interleukin-1 receptor antagonist in young and aged/co-morbid rodents after cerebral ischemia

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Highlights • IL-1β is a key proinflammatory cytokine involved in ischemic brain damage.• Administration of IL-1Ra improves the stroke outcome in young and co-morbid rats.• Acute IL-1Ra administration also promotes… Click to show full abstract

Highlights • IL-1β is a key proinflammatory cytokine involved in ischemic brain damage.• Administration of IL-1Ra improves the stroke outcome in young and co-morbid rats.• Acute IL-1Ra administration also promotes neurogenesis after experimental stroke.

Keywords: receptor antagonist; morbid; reparative effects; antagonist young; effects interleukin; interleukin receptor

Journal Title: Brain, Behavior, and Immunity
Year Published: 2017

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