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Modifications to the “Classical” Autologous Hematopoietic Stem Cell Transplantation in Multiple Sclerosis: A Less Toxic Approach is Feasible and Improves the Neurological Condition. A Mexican Perspective

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ered as an ordinal variable (better, stable, worse) due to the lack of standardized response assessment. Results: For the 33 patients included in the analysis, median age was 55 years,… Click to show full abstract

ered as an ordinal variable (better, stable, worse) due to the lack of standardized response assessment. Results: For the 33 patients included in the analysis, median age was 55 years, and 21(64%) males. Seventeen patients (51%) underwent ASCT as first or later line therapy, 13 (39%) received PCDT (excluding steroids) as first or later line therapy. and 10 patients received other therapies. Two patients underwent ASCT twice for total of 19 ASCTs. Eight (42%) ASCT were performed as 1st line treatment and 11 (58%) as later line treatments. Four patients received melphalan 200 mg/ m2, 3 at 140 mg/m2 and for the remaining patients the dose of melphalan was unknown. No patients died within 100 days from ASCT. Across all lines of therapy, 14 patients (82%) had clinical improvement after ASCT compared to 54% of patients treated with PCDT and 27% treated with other immunomodulatory drugs. Overall, 63 % of patients receiving an ASCT achieved a complete hematologic response/ very good partial response (CR/VGPR) compared to 23 % with PCDT or other therapies. Overall, clinical response rates for patients ever achieving CR/VGPR or better was 93% versus 37% for those achieving

Keywords: response; line; modifications classical; later line; transplantation; classical autologous

Journal Title: Biology of Blood and Marrow Transplantation
Year Published: 2018

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