LAUSR

Introduction The preapheresis peripheral blood CD34+ cell count (PBCD34) is the most important predictor of a good mobilization. Flow cytometry is not always immediately available in our country, therefore looking for another surrogate marker to predict CD34+ counts would be useful. Lactate dehydrogenase (LDH) has been correlated to higher PCBCD34. Objective We aim to investigate if LDH difference is a reliable tool to predict a poor mobilization in our patients. Methods We included all patients who receive an autologous transplant from January 2015 to September 2018. Demographic and laboratory characteristics were obtained, including complete blood count, preapheresis PBCD34 and DHL (table 1). Poor mobilization was defined as a final PBCD34+ count Results Seventy four patients were included. Median age was 43 years (11-72 years), 48% female, diagnosis were 31 myeloma multiple, 19 non Hodgkin lymphoma, 7 Hodgkin disease, 17 others. An adequate yield of CD34+ cells/kg was collected in 64 patients (86%). Preapheresis PBCD34+ had a stronger correlation with the difference of recollection minus basal LDH (Rho = 0.44, p = 0.001) than with monocytes (Rho = 0.189, p = 0.119). The area under the curve for LDH difference was 0.83 (p = 0.001, CI95% 0.72-0.95) (figure 1). Conclusion LDH difference is a good predictor of poor mobilization, with the main advantage that is a fast, cheap and easy marker to perform. It would be useful particularly in centers with poor access to flow cytometry or where the CD34+ count is delayed.