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Inducible regulatory T cells (iTreg) are a promising therapeutic cell source that exhibit Foxp3 expression and suppressive functions similar to natural regulatory T cells. Nonetheless, their clinical potential is limited… Click to show full abstract
Inducible regulatory T cells (iTreg) are a promising therapeutic cell source that exhibit Foxp3 expression and suppressive functions similar to natural regulatory T cells. Nonetheless, their clinical potential is limited by the instability of Foxp3 expression and T cell exhaustion that occurs during ex vivo expansion. We postulated that mesenchymal stromal cells (MSCs) could enhance the function and stability of iTregs due to their diverse immunomodulatory properties. In this study, we report that human bone marrow mesenchymal stromal cells (hBM-MSC) enhanced the stability of Foxp3 expression (media: 88.2 ± 1.7% vs. MSC platform: 96.2 ± 1.1%, n=7; p
Journal Title: Biology of Blood and Marrow Transplantation
Year Published: 2019
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