LAUSR

Allogeneic hematopoietic transplantation (allo-HCT) causes various pulmonary comorbidities including bronchiolitis obliterans (BO), interstitial pneumonia (IP) and pulmonary infectious disease. Smoking is a well-known risk factor of pulmonary dysfunction such as chronic obstruction pulmonary disease. Although smoking probably increases pulmonary comorbidities in allo-HCT patients, the relationship between number of cigarettes and allo-HCT has not been clearly elucidated. In this study, we retrospectively analyzed survival outcomes of 408 patients who received allo-HCT at our center between June 2007 and May 2019 according to pack-years (number of cigarettes smoked per day/20 multiplied by years smoked). The cutoff of 10 pack-years was defined by receiver operating characteristic (ROC) curves. In the univariate analyses, non-relapse mortality (NRM) and overall survival (OS) were inferior in the patients with > 10 pack-years history (n = 171) than those with ≤ 10 pack-years (n = 237) including non-smokers (1y-NRM 26.6% vs 13.9%, P