LAUSR

The long noncoding RNA (lncRNA) MIR31 Host Gene (MIR31HG) is a crucial regulator in malignant cancers. In this work, I examined the potential function and molecular mechanism of MIR31HG in cervical carcinoma progression. MIR31HG was strikingly upregulated in clinical cervical carcinoma specimens compared with that in adjacent samples. Functionally, knockdown of MIR31HG noticeably repressed cervical carcinoma cell growth and invasiveness in vitro and inhibited cervical carcinoma cell growth in vivo. Mechanistically, MIR31HG was identified as an endogenous 'sponge' through competing for miR-361-3p binding to modulate the miRNA target, epithelial membrane protein 1 (EMP1). Lastly, I verified that overexpression of EMP1 or miR-361-3p silencing effectively offset the impacts of MIR31HG knockdown on cervical carcinoma cell progression. In brief, these experimental results validate that MIR31HG is an oncogenic lncRNA that facilities cervical cancer progression.