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The aqueous humor proteome is intrinsically disordered

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Highlights • Our study demonstrated that intrinsic disorder is abundant in the aqueous humor.• The 749 aqueous proteins analyzed were enriched with disorder-promoting residues.• 208 aqueous humor proteins were predicted… Click to show full abstract

Highlights • Our study demonstrated that intrinsic disorder is abundant in the aqueous humor.• The 749 aqueous proteins analyzed were enriched with disorder-promoting residues.• 208 aqueous humor proteins were predicted to be highly intrinsically disordered.• Misregulation of IDPs may promote pathology in the aqueous humor.• IDPs in aqueous humor may serve as future targets for novel therapeutics.

Keywords: humor proteome; aqueous humor; proteome intrinsically; pathology; intrinsically disordered; humor

Journal Title: Biochemistry and Biophysics Reports
Year Published: 2022

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