LAUSR

Abstract The need for new analogues with higher efficacy to combat the multidrug-resistant microbes as well as other health implications is the need of the hour. Medicinal chemistry has been focused highly in this regard by researchers, due to labour and redundancy of new skeletons in the conventional mode of natural product discovery. However, the less toxicity imposed by natural products would definitely provoke an interest in developing new analogues from natural sources. Microbes especially endophytes having high metabolic diversity have been an aid to attending the prerequisite clinical challenges. The insights of biosynthetic gene clusters of endophytes have proven to be more potential in drug lead discovery. The epigenetic changes in microbial biosynthetic gene clusters would envision new possible skeletal structural diversities. This review is focused on the modulation as well as activation strategies of the biosynthetic gene clusters for biosynthesizing products with pharmaceutical importance along with possible regulatory elements involved in the expression.