LAUSR

Abstract The aim of this study and experiments was to estimate the anti-diabetic and hepatoprotective effect of Brassica oleracea sprouts extract in streptozotocin induced diabetic rats. Diabetes is induced in rats by intra-peritoneal injection of Streptozotocin. Diabetes introduction was verified 3 days post administering Streptozotocin, when an elevated blood sugar level was observed in rats. Scheduled doses of methanolic extract of Brassica oleracea sprouts were given to the diabetic rats. The duration of this experiment was 28 days. Rats were made to fast overnight for oral glucose tolerance test; antioxidant parameters were also estimated. After this, these rats were euthanized for histopathological studies. One of the three doses of methanolic extract of Brassica oleracea sprouts showed results almost similar and sometimes even better than Glibenclamide (standard drug used for the experiment). Depletion in blood glucose level was seen after administering Broccoli extract doses. Effects on HOMA-IR and HOMA- β, plasma insulin level, glycated hemoglobin and several other parameters was seen to be positive. Also, antioxidant parameters, GLUT2 and SGLT1 showed enhancement in diabetic condition of rats. It can be inferred that methanolic Brassica oleracea sprouts extract had a noteworthy effect on Streptozotocin induced rats. Especially 200 mg/kg dose had an impressive results record. Elevated levels of GLUT2 and SGLT1 in rats were reduced on treatment with Brassica oleracea sprouts extract. This shows that our broccoli extract has a remarkable anti-diabetic effect.