LAUSR

Abstract Diabetes mellitus (DM) is a major contributing factor to cardiovascular disease (CVD) and heart failure. In this current research work, we aimed to attenuate cardiac toxicity and DNA damage in experimental diabetes by administration of quercetin nanoemulsion. Different concentrations of stabilizing agents and surfactant agent (Tween 80) were used as covering coat for the formed quercetin nanoemulsion QCTN. Additionally, depending on the utilized concentration of Tween 80, three different QCTN nanoemulsion were produced and nominated as QCTN-1, QCTN-2 and QCTN-3. The three different nanoemulsions had different sizes in nanometers. Different tools were utilized to examine the particle shape, hydrodynamic size, and zeta potential studies. Methods: fifty-six male albino rats were used in this study and divided into seven groups including control, diabetic, quercetin, and treated groups. Blood glucose level, oxidative stress, and inflammatory markers were determined. In addition, cardiac indices and enzymes were also estimated. The findings illustrated that there is a significant elevation in cardiac indices and enzymes in the diabetic group compared to control. Whereas quercetin significantly attenuated these all parameters. In addition, QCTN-2 that exhibited the smallest size (53 nm) and excellent zeta potential (-36 mv) provided the best impact as shown from the treated diabetic rats (treated III) followed by QCTN-1 and finally the treated rats (treated IV) that injected with QCTN-3 which is still more potent than QCT alone. These results indicated the role of therapeutic nanoemulsion in enhancing polyphenolic compounds like quercetin.