LAUSR

Abstract Background and purpose of the study: The goal was to evaluate the effects of ethanolic extract of Clerodendrum paniculatum flower (CPF) on antidiabetic and antilipidemic tests indices of experimentally-induced hyperglycemic rats. Methods High Fat Diet (HFD) treated Streptozotocin (STZ) induced diabetic rats were used for this study. The acute toxicity of ethanolic extract of C. paniculatum flower (2000mg/kg body weight) and antidiabetic effect of CPF (200mg/kg body weight) were studied in rats. Glibenclamide (1.25mg/kg body weight) was used as a reference drug. For antihyperglycemic evaluation, glucose,C-peptide, Insulin, Haemoglobin and glycosylated haemoglobin (HbA1c) levels were analyzed. Low density lipoprotein (LDL), High density lipoprotein (HDL), triglycerides and total cholesterol were analyzed in rats. The enzymic antioxidant activity (super oxide dismutase (SOD), glutathione peroxidase (GPx), reduced glutathione (GST) and Catalase) and non-enzymic antioxidant activity (vitamin C, vitamin E and glutathione reductase) of C. Paniculatum flower were evaluated. Important carbohydrate metabolizing enzymes like Glucose 6-phosphatase, Fructose 1and 6diphosphatase and hexokinase were determined in experimental rats. Results After the oral administration of CPF extract significantly reduced glucose levels and cholesterol values. Extract improved enzymic and non enzymic antioxidant levels. Conclusion C. paniculatum flower extract is useful in controlling blood glucose level as well as improving lipid metabolism and body weight in rats with induced diabetic rats.