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The phytochemical investigation of Andrographis paniculata resulted in the isolation of a novel 15-spiro diterpenoid dimer bisandrographolide G (1). Its structure was determined by 1D and 2D NMR, HRESIMS, electronic… Click to show full abstract
The phytochemical investigation of Andrographis paniculata resulted in the isolation of a novel 15-spiro diterpenoid dimer bisandrographolide G (1). Its structure was determined by 1D and 2D NMR, HRESIMS, electronic circular dichroism (ECD), and TD DFT calculations of ECD spectra. It showed potent inhibitory activity against human carboxylesterase 2 (CES 2) with an IC50 value of 4.61 ± 0.23 μM, and it was defined as a mixed-competitive type inhibitor with a Ki value of 8.88 μM based on the inhibition kinetics result. This finding gave us a hit to develop new generation of human CES 2 inhibitors.
Journal Title: Bioorganic chemistry
Year Published: 2020
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