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capacity to bind tomembranes.We also performed atomisticmolecular dynamics simulations to determine whether the first thirty N-terminal residues are able to detach from the core of the protein in its monomeric… Click to show full abstract
capacity to bind tomembranes.We also performed atomisticmolecular dynamics simulations to determine whether the first thirty N-terminal residues are able to detach from the core of the protein in its monomeric and dimeric forms and their role in the mechanism. Moreover, our findings support the importance of dimer formation, which seems to be a functional intermediate in the assembly pathway of different pore-forming proteins. These findings support the hybrid pore proposal mechanism as a universal model of actinoporin pore formation.
Journal Title: Biophysical Journal
Year Published: 2017
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