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Peptide Nucleic Acids, DNA mimics featuring a peptide-like backbone and nucleobases that bind nucleic acids, are capable of impacting gene expression, are resistant to degradation, and show promise as therapeutic… Click to show full abstract
Peptide Nucleic Acids, DNA mimics featuring a peptide-like backbone and nucleobases that bind nucleic acids, are capable of impacting gene expression, are resistant to degradation, and show promise as therapeutic agents. PNAs are cell-impermeant and intracellular delivery has been a challenge, however cell-penetrating peptides show some promise as delivery vehicles. To identify sequences that improve nuclear PNA delivery we constructed a library of 8192 unique peptide sequences based on the well-known cell penetrating peptides Tat and Penetratin.
Journal Title: Biophysical Journal
Year Published: 2017
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