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Transient potential receptor ion channel vanilloid member 1, TRPV1, was initially identified as the capsaicin receptor, but is also modulated by various chemical and physical stimuli including elevated temperature, acidic… Click to show full abstract
Transient potential receptor ion channel vanilloid member 1, TRPV1, was initially identified as the capsaicin receptor, but is also modulated by various chemical and physical stimuli including elevated temperature, acidic pH, endogenous ligands and regulatory proteins. TRPV1 functions as a primary heat sensor in humans. Recently determined structures of rat TRPV1 have provided a better understanding of channel architecture and the ligand gating. However, the mechanism of how thermal stimulus is integrated and converted to channel gating remains poorly understood.
Journal Title: Biophysical Journal
Year Published: 2017
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