LAUSR

Abstract A chemical investigation of the extract of the marine-sponge-associated fungus P. colombiensis resulted in the isolation of eight chlorinated benzophenone derivatives, named, pestalone (1), pestalachlorides A-C, E, and F (2-6), pestalalactone (7), and pestalalactone atropisomer (8). The structures of these compounds were identified by spectroscopic analysis (MS, 1D/2D NMR) and comparison with the previously reported data . Compounds (1–8) were isolated from this species for the first time. Moreover, compounds (1–8) had not been reported from any other genus , and the chemotaxonomic signifcance of eight chlorinated benzophenone derivatives (1–8) was also discussed.