LAUSR

Abstract The current study presents a comparison within the framework of 45S5 Bioglass® composition, between two types of coatings, achieved by physical or chemical means. The oxide composition was established within SiO2–P2O5–CaO–MgO–SrO–Na2O system, while the preparation techniques were pulsed laser deposition and spin coating. The target necessary for laser ablation experiments was achieved via sol-gel route, displaying a quite well-densified microstructure, as well as modified combeite and akermanite as crystalline phases. The resulting layers turned out to be continuous, homogeneous, partially crystalline and nanostructured in texture. The physical approach led to thicker films, which completely veiled the surface irregularities of substrate; moreover, they provided higher apatite-forming ability and better performance in terms of biocompatibility with human fibroblast BJ cells.