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Biochemical similarity between cultured chondrocytes and in situ chondrocytes by chemometric analysis from FTIR microspectroscopy

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Highlights • Osteoarthritis is the most prevalent disorder of articular joints in humans.• Articular chondrocytes play a crucial role in the production and maintenance of the extracellular matrix in cartilage… Click to show full abstract

Highlights • Osteoarthritis is the most prevalent disorder of articular joints in humans.• Articular chondrocytes play a crucial role in the production and maintenance of the extracellular matrix in cartilage of synovial joints.• Autologous chondrocyte implantation is an emerging therapy for articular injuries.• It is important characterize cultured chondrocytes before implantation.• Fourier transform infrared (FTIR) spectroscopy could result in a powerful tool in the study and characterization of cultured cells• There is a biochemical similarity between articular and cultured chondrocytes by chemometric analysis using FTIR microspectroscopy.

Keywords: chondrocytes chemometric; ftir microspectroscopy; cultured chondrocytes; biochemical similarity; chemometric analysis

Journal Title: Biotechnology Reports
Year Published: 2019

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