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Osthole extracted from a citrus fruit that affects apoptosis on A549 cell line by histone deacetylasese inhibition (HDACs)

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Highlights • The grapefruit osthole act as a natural inhibitor of HDACs.• Osthole inhibited the growth of A549 cells, in a time- and concentration-dependent manner.• Ostholeinduced apoptosis and the caspase-9… Click to show full abstract

Highlights • The grapefruit osthole act as a natural inhibitor of HDACs.• Osthole inhibited the growth of A549 cells, in a time- and concentration-dependent manner.• Ostholeinduced apoptosis and the caspase-9 was also increased by osthole treatment.

Keywords: osthole extracted; hdacs osthole; citrus fruit; hdacs; extracted citrus; fruit affects

Journal Title: Biotechnology Reports
Year Published: 2020

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