LAUSR

Fucoidans, sulfated polysaccharides in brown algae, were depolymerized though high-pressure hydrolysis, and their antibacterial activity, structural properties, and antibacterial mechanisms were investigated in this work. The fucoidans from Laminaria japonica show no antibacterial activity before depolymerization; however, their depolymerized products can effectively (p<0.05) inhibit the proliferation of Escherichia coli (E. coli) and Staphylococcus aureus (S. aureus). The structure-activity study demonstrated that lower molecular weight and stronger polyanionic property can promote the antibacterial activity. And the depolymerized fucoidans exhibited better antibacterial activity against E. coli than against S. aureus. The results also indicated that the bactericidal pathway of depolymerized fucoidans should be through destruction of the cytomembranes and the target molecules are the membrane proteins, which can result in changed membrane fluidity and/or activated autophagocytosis. Therefore, the depolymerized fucoidans possess potential appliance values in partly or totally replacing antibiotics in our daily life.