LAUSR

Background Adaptive AV shortening algorithms have demonstrated QRS duration (QRd) narrowing in traditional cardiac resynchronization therapy (CRT) patients. Multipoint pacing (MP) has also demonstrated benefit in these patients. An additional site of activation via intrinsic conduction of the septum may further contribute to CRT response, however incorporation of all of these strategies together has yet to be developed or investigated. Objective We developed and tested a method combining MP-CRT and controlled septal contribution to create MP-Fusion encouraging 4 ventricular activation sites for CRT patients utilizing measurements from intracardiac electrograms and incorporation of an AV delay shortening algorithm (Sync-AVTM Abbott laboratories, Sylmar Ca.) Methods Patients with intact AV conduction Results 13 (N=17) patients were analyzed 65.5 +/- 8.3 years. (M:F /Age/) Mean baseline QRSd was 148ms (+/-22.14). Programming utilizing the MP-fusion algorithm yielded a QRSd of 113.23ms (+/-17.14) (P Conclusion The simple use of MP-fusion demonstrated significant QRSd narrowing in all patients tested. A randomized trial with larger sample size and outcome measures in addition to QRSd is warranted.