LAUSR

Objectives To evaluate the prognostic value of serum sodium level on admission for in-hospital mortality (IHM) in patients hospitalized with heart failure (HF). Methods A total of 4347 consecutive patients admitted for HF to Heart Failure Center, Fuwai Hospital between December 2009 and December 2019 were enrolled in this study. Patients were divided into three groups according to serum sodium level on admission: hyponatremia (sodium level 145 mmol/L). The clinical characteristics of the three groups were compared, and the relationship between serum sodium level and IHM was evaluated. Multivariate logistic regression analysis was used to determine the risk factors of IHM. Results The serum sodium level on admission was (137.1 ± 4.4) mmol/L with a range from 115.6 mmol/L to 160.9 mmol/L, of which, hyponatremia was 25.2% (n = 1097), normal sodium level was 72.6% (n = 3156) and hypernatremia was 2.2% (n = 94). Compared with those in the normal sodium group, patients in dysnatremia (including hyponatremia and hypernatremia) group were older, had higher NYHA functional status and lower left ventricular ejection fraction (LVEF) (P Conclusions Dysnatremia (both hyponatremia and hypernatremia) is one of the most relatively common electrolyte disorders in patients hospitalized with HF. Patients with dysnatremia on admission had higher risk of IHM. Dysnatremia was an independent predictor of IHM in patients hospitalized with HF.