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One-pot carbon-Ferrier rearrangement of glycals with unactivated aryl methyl ketones has been developed under mild Silyl triflate catalysis. Keto methyl group of various aryl methyl ketones without being converted into… Click to show full abstract
One-pot carbon-Ferrier rearrangement of glycals with unactivated aryl methyl ketones has been developed under mild Silyl triflate catalysis. Keto methyl group of various aryl methyl ketones without being converted into silyl enol ether could directly attack anomeric position of glycals to form keto functionalized C-glycosides in moderate to good yields with high α-selectivity. The versatility of this method has been extended to the synthesis of a small library of chromanone 3-C-glycosides.
Keywords:
ferrier rearrangement;
chromanone glycosides;
rearrangement glycals;
one pot;
carbon ferrier
Journal Title: Carbohydrate research
Year Published: 2017
Link to full text (if available)
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Journal Title: Carbohydrate research
Year Published: 2017
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!