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A novel series of nucleosides with potential antiviral activity have been synthesized and characterized using IR, MS, 1D NMR and 2D NMR data. The antiviral activity of the synthesized compounds… Click to show full abstract
A novel series of nucleosides with potential antiviral activity have been synthesized and characterized using IR, MS, 1D NMR and 2D NMR data. The antiviral activity of the synthesized compounds was assessed against the Coxsackie B virus and Hepatitis A virus (HAV-10). The results revealed that compound 6 is equipotent to the standard drug Ribavirin against HAV-10. Also, some computational studies, such as the prediction of pharmacokinetic properties, toxicity, and bioactivity, have been done.
Keywords:
nucleosides potential;
synthesis antiviral;
dft molecular;
docking studies;
molecular docking;
antiviral dft
Journal Title: Carbohydrate research
Year Published: 2021
Link to full text (if available)
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Journal Title: Carbohydrate research
Year Published: 2021
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!