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A heterogeneous catalytic and solvent-free approach to 1,2-dihydroquinoline derivatives from aromatic amines and alkynes by tandem hydroarylation-hydroamination

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Abstract This study describes a mesoporous aluminosilicate (ASM) catalyst-induced one-step synthesis of substituted dihydroquinolines through a hydroarylation/hydroamination cascade reaction under solvent-free conditions. A sol-gel method was utilized to prepare the… Click to show full abstract

Abstract This study describes a mesoporous aluminosilicate (ASM) catalyst-induced one-step synthesis of substituted dihydroquinolines through a hydroarylation/hydroamination cascade reaction under solvent-free conditions. A sol-gel method was utilized to prepare the ASM catalyst using tetraethyl orthosilicate (TEOS) and aluminum nitrate (Al(NO3)3.9H2O). The catalytic protocol, utilizing simple starting materials and a heterogeneous catalyst in a clean reaction environment, is considered an alternative and economically viable route to synthesize a wide range of 1,2-dihydroquinoline derivatives.

Keywords: dihydroquinoline derivatives; solvent free; hydroarylation hydroamination

Journal Title: Catalysis Communications
Year Published: 2020

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