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Singling Out Chromosome Gains in Tumor Evolution.

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In this issue of Cancer Cell, Sheltzer et al. shed new light on Theodor Boveri's century-old hypothesis by demonstrating that aneuploidy characterized by single-chromosome gains acts to suppress tumorigenesis and that… Click to show full abstract

In this issue of Cancer Cell, Sheltzer et al. shed new light on Theodor Boveri's century-old hypothesis by demonstrating that aneuploidy characterized by single-chromosome gains acts to suppress tumorigenesis and that aneuploidy itself is a nidus for genomic instability.

Keywords: singling chromosome; gains tumor; chromosome gains; tumor evolution; chromosome

Journal Title: Cancer cell
Year Published: 2017

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