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HDAC Inhibitors Finally Open Up: Chromatin Accessibility Signatures of CTCL.

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In this issue of Cancer Cell, Qu et al. describe the chromatin accessibility profiles of cutaneous T cell lymphoma, with dynamic assessments of response and resistance to histone deacetylase inhibitor therapy. Their… Click to show full abstract

In this issue of Cancer Cell, Qu et al. describe the chromatin accessibility profiles of cutaneous T cell lymphoma, with dynamic assessments of response and resistance to histone deacetylase inhibitor therapy. Their "personal regulome" analysis framework reveals chromatin features that may be predictive of clinical response to epigenetic therapy.

Keywords: finally open; hdac inhibitors; accessibility; open chromatin; inhibitors finally; chromatin accessibility

Journal Title: Cancer cell
Year Published: 2017

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