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It's ALL in the Family: IKZF1 and Hereditary Leukemia.

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IKZF1 plays an essential role in lymphopoiesis, and somatic IKZF1 variants in acute lymphoblastic leukemia (ALL) are associated with poor prognosis. In this issue of Cancer Cell, Churchman et al. add… Click to show full abstract

IKZF1 plays an essential role in lymphopoiesis, and somatic IKZF1 variants in acute lymphoblastic leukemia (ALL) are associated with poor prognosis. In this issue of Cancer Cell, Churchman et al. add to the list of leukemia predisposition genes with the identification and characterization of germline IKZF1 variants in childhood ALL.

Keywords: hereditary leukemia; family ikzf1; ikzf1 hereditary; leukemia; ikzf1

Journal Title: Cancer cell
Year Published: 2018

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