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CAR T cells with different costimulation domains have proven clinical efficacy in leukemia and lymphoma but have different kinetics of activation, antigen sensitivity, and susceptibility to exhaustion. Two recent studies identified… Click to show full abstract
CAR T cells with different costimulation domains have proven clinical efficacy in leukemia and lymphoma but have different kinetics of activation, antigen sensitivity, and susceptibility to exhaustion. Two recent studies identified that these functions are shaped by a balance among opposing signaling complexes and transcription factors competing for binding motifs.
Keywords:
unraveling signaling;
car;
activation;
car cells;
exhaustion;
balance
Journal Title: Cancer cell
Year Published: 2020
Link to full text (if available)
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Journal Title: Cancer cell
Year Published: 2020
Link to full text (if available)
Share on Social Media: Sign Up to like & get
recommendations!