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Adoptive transfer of tumor-specific Th9 cells eradicates heterogeneous antigen-expressing tumor cells.

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In this issue of Cancer Cell, Xue et al. demonstrate that adoptive transfer of tumor-specific Th9 cells can eradicate established tumors containing antigen-loss-variant cells (ALVs) through both direct killing and bystander… Click to show full abstract

In this issue of Cancer Cell, Xue et al. demonstrate that adoptive transfer of tumor-specific Th9 cells can eradicate established tumors containing antigen-loss-variant cells (ALVs) through both direct killing and bystander effects mediated by intratumoral accumulation of extracellular ATP (eATP) that promotes monocyte infiltration and stimulation of IFNα/β production.

Keywords: th9 cells; tumor specific; adoptive transfer; transfer tumor; specific th9; tumor

Journal Title: Cancer cell
Year Published: 2021

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